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Rabbit Anti-MYD88

價格：電議

采購度：302 原產(chǎn)地：其它

發(fā)布時間：2018/6/25 11:06:50

Rabbit Anti-MYD88 The pro-inflammatory cytokine IL-1 induced cellular response requires IL-1 receptor complex including IL-1RI and IL-RAcP.

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標(biāo)簽：Rabbit Anti-MYD88

詳細(xì)信息

Rabbit Anti-MYD88
Background: The pro-inflammatory cytokine IL-1 induced cellular response requires IL-1 receptor complex including IL-1RI ａnd IL-RAcP. Recently, MyD88 was identified as an adapter molecule in the IL-1 signaling pathway (Muzio et al. 1997). MyD88 associates with ａnd recruits IRAK to the IL-1 receptor complex in response to IL-1 treatment ａnd dominant negative form of MyD88 attenuates IL-1R mediated NF-kB activation. MyD88 is also employed as a regulator molecule by IL-18 receptor ａnd human Toll receptor (Adachi et al. 1 998; Medzhitov et al. 1998), which are members in the Toll/IL-1R family of receptors. Targeted disruption of the MyD88 gene results in loss of cellular responses to IL-1 ａnd IL-18, ａnd MyD88-defecient mice lack responses to bacterial product LPS that employs Toll-like receptors 2 ａnd 4 (TLR2 ａnd TLR4) as the signaling receptors. MyD88 is a general adapter protein for the Toll/1R family of receptors ａnd plays an important role in the inflammatory response induced by cytokines IL-1 ａnd IL-18 ａnd endotoxin. MyD88 gene is expressed in many tissues.

specificity :
–Anti- MYD88 is a rabbit polyclonal antibody unconjugated
–specific for MYD88 of human, mouse ａnd rat,chicken
–use for western blotting,elisa,immunoprecipitation ａnd immunohistochemistry
–Protein G affinity chromatography purification, purity :>95%
–Isotype: IgG
–mol wt: 34kDa

Application :
–Western blotting 1:100-500
–Immunohistochemistry 1:100-500
–ELISA 1:500-1000
–Optimal working dilutions must be determined by the end user.
Storage: Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20℃. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody, the antibody is stable for at least six weeks at 2-4 ℃
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

更新時間：2024/11/18 9:49:20

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